CBG the Lesser Known Cannabinoid

The mainstreaming of medical marijuana and the accompanying green rush have prompted an industry-wide interest in extracting and isolating cannabinoids believed to have therapeutic potential.

Cannabidiol (CBD) is often erroneously considered the “medical” counterpart to buzz-inducing tetrahydro cannabidiol (THC), and the economic buzz around the newly publicized cannabinoid has the industry scrambling to identify other cannabinoids responsible for the medical benefits of the cannabis plant.

The search is on for “the next CBD,” and industry pioneers like GW Pharmaceuticals appear to have set their sights on cannabigerol (CBG), a much lesser-known cannabinoid, but one necessary for the production of the plant’s more famous ingredients: as the “stem cell” of cannabis, CBG is the first cannabinoid present in the plant and converted into THC, CBD, and other cannabinoids by the time of harvest.

Most of the research into CBG has focused on its transitional properties as key to understanding the development of the cannabis plant, but its importance to the plant’s development has attracted a swell of interest in its own potential medical properties.

CBG has been linked to treatment of a long host of ailments — including glaucoma, cancer, Huntington’s Disease, pain and nausea — and the industry is talking about the compound’s potential. CBG has similar benefits to CBD, but acts on other neurotransmitters.

Research into CBG is still in its infancy, limited to pre-clinical trials and animal studies that offer more suggestions than conclusions.

Paul Armentano, deputy director of NORML, said clinical research in CBG is growing.

“Despite CBG being isolated in 1964, there are relatively few peer-reviewed assessments of its potential therapeutic properties,” he said. “That said, there appears to be a renewed interest among scientists regarding non-THC cannabinoids and their potential medical application, so my supposition is that we will begin to see a greater emphasis on CBG and other non-euphoric inducing phytocannabinoids (cannabinoids which originate from plants).”

Researching the cannabis plant is a complicated undertaking due to prohibition’s chilling effect on funding, as well as the tendency for research to focus on extracted cannabinoids rather than their collective effect.

Just as nutritionists have touted the importance of whole-plant foods, cannabis researchers are pointing to an “entourage effect” that employs not just one or two, but a combination of several cannabinoids acting together on different receptors in the brain.


More at: Cannabis Now

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