MMJ STUDY Medicinal Marijuana vs Stress Related Illnesses


Extended periods of stress can lead to a harmful response of the immune system known as inflammation. Over past decades, studies have linked chronic stress to not only depression and fatigue, but more severe neurological disorders as well. 

Yet marijuana, a well-known stress reliever, may be able to prevent these ailments, according to new findings published in the British Journal of Pharmacology.

Researchers at the Complutense University of Madrid in Spain conducted a number of experiments with rats and found by activating certain marijuana pathways, they were able to reverse the inflammatory response caused by chronic stress.

The pathways, known as CB2 receptors, are found on many immune cells in the body and act to regulate their activity. 

“In conclusion, we have found evidence of an anti-inflammatory profile for CB2 receptor activation,” wrote Dr. Borja García-Bueno and his team. 

The researchers add that targeting these pathways could be useful “for the treatment of stress-related pathologies with a neuroinflammatory component, such as depression.” 

While the study involved JWH-133, a synthetic chemical that targets CB2 receptors specifically, the authors note that similar results have been obtained by targeting CB1 receptors as well.

CB1 receptors are responsible for the marijuana high, while CB2 receptors are not. As such, scientists have begun to focus on chemicals that can target CB2 pathways exclusively.

Nevertheless, the team concludes that drugs which act on both CB1 and CB2 pathways may hold promise for the management of stress-related neurodegenerative and neuropsychiatric diseases.
 
Source: Leaf Science

STUDY Marijuana may Reduce Brain Damage Caused By Alcohol


Too much alcohol can lead to permanent brain damage, but a new study suggests marijuana may be able to prevent this. 

Published last week in the journal Pharmacology Biochemistry and Behavior, scientists from the University of Kentucky and University of Maryland concluded that a chemical in marijuana called cannabidiol (CBD) could be used to ward off alcohol-induced brain damage. 

They hope the findings will bring them closer to developing a preventative treatment for patients suffering from alcoholism. 


“These results justify further preclinical development of transdermal CBD for the treatment of alcohol-induced neurodegeneration.”

Like THC, CBD is another chemical found in marijuana – but CBD cannot get you high. However, both chemicals are strong antioxidants – a characteristic the authors believe to be responsible for reducing brain damage from alcohol. 

“It has been suggested that the neuroprotective effects of CBD observed during binge alcohol induced neurodegeneration are due to its high antioxidant capacity.”

The authors also note that CBD acts as a stronger antioxidant than many well-known antioxidants – including BHT and α-tocopherol (vitamin E)

In the new study, researchers tested CBD treatment on rat models using both a skin patch (transdermal) and regular needle injection (intraperitoneal). Both methods appeared to produce “similar magnitudes of neuroprotection” – approximately 50 per cent, according to their analysis. 


“Interestingly, this study showed that transdermal and IP [intraperitoneal] delivery of CBD produced similar magnitudes of neuroprotection.”

Although further studies need to be done before human trials begin, the researchers state that – while treatments for alcoholism do exist – none have yet to target the neurodegenerative effects of alcohol.
The neurodegenerative effects are believed to contribute to alcohol dependence by impairing behavioral control and decision making.

Studies show about 8.5% of the U.S. population may be suffering from alcohol dependence, suggesting that many stand to benefit from this new potential treatment.

Read More: Truth on Pot

MMJ Something to think about before Growing your Medicine Indoors.

photo via Weedist Community on Pinterest

Have you been thinking about growing and producing your own medicine indoors? It certainly does sound like a great way to lower your medicinal marijuana expenses. However, there are some hidden costs and considerations that must be realized before starting your own indoor horticulture adventure.

The Stink Factor

If you are growing within the confines of your home, don’t forget some kind of ventilation or some kind of de-stinkification device. Any way you slice it, there will be a stink factor.

Because of the stink factor, keeping the grow area as far away from the living areas and your clothing, might be wise. Yes, this does eliminate some of those good old closet grows but taking the fragrance with you might be hazardous in some social situations.

Unless you have a palatial estate your little hobby might be a little close for comfort when the non-toking friends or family come to visit. You might consider limiting your social interaction right before harvest time or maybe think again about ventilation or some kind of air filtration system for that sweet but illicit aroma.

Utility Bills

Depending on your setup, your utility bills may or may not be significantly affected but there will be some additional costs no matter what.

It does not take long to have a lot of plugs in a lot of sockets. After all there is more than just lights. It is quite easy to see a need for automatic watering, high intensity lamps, heaters, CO2 generators and a plethora of other gadgets and gizmos. However, If you see that power bill climbing, a little simplification and moderation may be in order.

Consider investing in LED lighting. LED lights are more expensive that CFL or incandescent but, over time, they pay for themselves because they last longer, sip electricity and don’t put a drain on your cooling system.

You might also consider scaling down the project to a “just what I need” approach. Access your medicinal needs and try not to go to far overboard when it comes to excess inventory.

Is it really the thing for you?

Will you have the patience? Are you willing to do the research and really get to know what you are doing? Can you keep it to your self?

Growing your own requires patience. As much as you want to get those seeds cracked asap, a little careful preparation goes a long way.
 

Some of the most important preparation is in your education. Go out onto the web where you will find limitless numbers of blog posts, web site articles and YouTube videos on the subject matter. Learn the fundamentals and research the mistakes and pitfalls shared by other indoor growers.

Last but certainly not the least, can you keep it to yourself? As much pride of accomplishment you may feel, you cannot give regular tours of your masterpiece. It is just not wise to advertise what you are doing. Remember, all because you might be someone that can be trusted, does not mean you should burden others with the same mature responsibility.

Just one opinion.

CJ @CarverJohns on Twitter


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MMJ Make your own THC Pills


We all know smoking is bad right? If you don’t want to smoke and are looking for another way to get high without any of the harmful effects associated with smoking, or you need a way to get high and smoking isn’t a viable option (e.g. large events, public places, concerts etc)  then why don’t you try out these home-made THC pills? They are ridiculously easy to make…

The concept is simple – it’s a capsule filled with a mixture containing THC that’s ready to be absorbed into your system.  The dose is easy to control as well.

You will need:

1.Olive/Vegetable oil

2.Cannabis (your chosen amount)


3.Something that will grind up the cannabis


4.Heat source e.g. Stove


5.Bowl (something to mix/grind the cannabis and oil in)


6.Pill Capsules (empty some vitamin capsules out)


7.Small spoon


Dose:
Everybody uses different amounts of cannabis.  As a rough guide, try making 5 capsules out of one gram of cannabis.  Non-experienced cannabis users should half this dose.


Step 1:
Get the amount of cannabis you would normally consume in a joint / bong hit – this is one dose.  We multiply to get however many doses you want to make. Each dose will be one capsule.


Step 2:
Put your finely ground herbs into a bowl and add enough oil to saturate it grind this for about a minute. Heat up a pan on the stove and transfer the mixture.

Step 3:
You’re going to want it about 120°C.  Let it heat up for 15 minutes, grinding it into a paste.


Step 4:
Let the mixture cool down.


Step 5:
Use the small spoon to transfer the mixture into the capsules. You’re good to go! Store them in the freezer.


This method of consumption is ideal for when you cannot smoke.  Remember that the way THC acts on your system when ingested is different to when smoked – it will take longer to hit you, and it may be more intense and last longer.

Source: iSmoke Magazine

STUDY Why we get The Munchies


It's one of the most well-known effects of marijuana: the powerful surge in appetite many users feel after smoking or ingesting the drug, colloquially known as "the munchies."

For medicinal users that have trouble eating due to chemotherapy, this can be one of the drug's biggest benefits. For recreational users, this benefit can also be rather enjoyable, if unkind on the waistline. But for years, scientists have struggled to understand how marijuana's active ingredient—tetrahydrocannabinol, or THC—stimulates appetite.

A new study in Nature Neuroscience brings us a bit closer to solving the mystery. A team of European neuroscientists led by Giovanni Marsicano of the University of Bordeaux has found that, in mice, THC fits into receptors in the brain's olfactory bulb, significantly increasing the animals' ability to smell food and leading them to eat more of it. A big part of the reason why you might eat more food after using marijuana, the research indicates, is simply that you can smell and taste it more acutely.

This effect of THC has to do with the underlying reason why the chemical affects the human brain so potently in the first place. Likely produced by the marijuana plant as a self-defense against herbivores who might feel disorientated after eating the plant and avoid it in the future, THC fits into receptors that are part of the brain's natural endocannabinoid system, which helps to control emotions, memory, pain sensitivity and appetite. Our brains typically produce their own chemicals (called cannabinoids) that fit into these same receptors, so by mimicking their activity, THC can artificially alter the same factors in dramatic ways.

The scientists began by exposing mice (increasingly used in neuroscientific research because of the surprising amount of cognitive similarities they share with humans) to banana and almond oils as a test of sensitivity to scent. When they did so, the mice sniffed the oils extensively at first, then stopped showing interest in them, a well-known phenomenon called olfactory habituation. Mice that were dosed with THC, however, kept on sniffing, demonstrating an enhanced sensitivity to the scents. These THC-dosed mice also ate much more chow when given the chance, showing an increased appetite.

The researchers also genetically engineered some mice to lack a type of cannabinoid receptor in their olfactory bulbs and subjected them to the same experiment. They found that even if these mice were given THC, it had no effect: They still habituated to the scent, showing that the drug's scent-enhancing powers involved activity in this region of the brain. In addition, these mice did not demonstrate an increased appetite when given the drug, showing that the "munchies" effect was dependent on olfactory lobe activity as well.

Read More: The Smithsonian 

MMJ Marijuana may relieve Symptoms of Asthma


Published in the British Journal of Pharmacology, a new study shows marijuana may have a similar effect on the airways as some asthma medications.

Using samples of human lung tissue, French researchers found that THC could block muscle contractions caused by a signaling molecule called acetycholine.

Acetycholine is responsible for maintaining muscle tone of the airways and also contributes to contractions in asthma attacks. Interestingly, asthma medications block the same molecule, but from a slightly different angle.

“They prevent the acetycholine from binding to its receptor,” explains Dr. Donald Tashkin, who was not involved with the study. “But THC works proximal to that. It doesn’t have any competitive effect for binding to receptors. It just prevents the acetylcholine from being released.”

Dr. Donald Tashkin, a lung expert and professor of medicine at UCLA, was part of the team that first discovered marijuana’s effect as a bronchodilator. In 1973, his group published a study in the New England Journal of Medicine that found airways widen in both healthy and asthmatic individuals after smoking marijuana.

In fact, Dr. Tashkin’s findings led to a number of subsequent studies on delivering THC through an inhaler. But the inhaler route didn’t work, he says, because THC was too large of a molecule and caused patients to cough.


Taking THC orally was also tried, but its effect on the airways was delayed and too weak.


And while researchers eventually concluded that smoking was the best route of administration, smoking seemed like a poor choice for delivering a treatment.

Read More: Leaf Science

7 Tips for Passing a Drug Test


When all else fails and you don’t have much time, drink a lot of water. Although it wont flush the drugs out of your system, if you drink an abundance of water it will dilute your urine sample to the point where the drug will most likely be below detection levels. However, be careful not to drink too much water at one time because you can risk over-hydrating your body.


If you know you have a drug test in the next few weeks, the best way to get clean is to workout. Sweating and burning fat helps rid your body of many toxins and is the fastest way to actually detox your body. Make sure to include weigh lifting and cardio in your workout routine and even sit in a sauna for a while afterwards if you can.


Taking a B-Complex Vitamin is definitely useful when passing a drug test. When you don’t have much time before your test and you’re drinking a lot of water, your urine will be very clear and diluted. Clear urine can be a red flag for lab technicians that are testing your sample. Vitamin B will help keep you urine a bright yellow color and avoid suspicion of dilution

Creatine

When drinking a lot of water to pass a drug test, try and take creatine pills along with Vitamin B. Creatinine is a byproduct of creatine and is found in urine. If your urine is too diluted from water, you’re creatinine levels will be low and lab technicians will take notice.

Low Fat & Low Carb Diet

Since some drug metabolites are stored in fat (especially THC), it is important to cut down your fat and carbohydrate intake as much as possible. Avoid dairy products and fatty meats. Lean meats such as chicken and turkey are ideal, along side vegetables and plenty of liquids.
  
Synthetic Urine

If your drug test is for a job or something that isn’t court related such as a probation drug test, chances are you will not be watched while you provide your urine sample. If this is the case, head to your local smokeshop and ask for synthetic urine. The product is relatively cheap and an average drug test cannot detect the difference between it and real urine. Keep it warm with a heating pad (usually included with the synthetic urine purchase) and pour it into the sample cup while in the bathroom.

Diuretics

Staying hydrated and urinating frequently is a huge part of passing a urine drug test. Drinks such as coffee, green tea and cranberry juice are common diuretics that will cause you to urinate frequently. Use the restroom as much as you can before your drug test and do not let your sample be your first urination of the day.


STUDY Marijuana may help those who struggle with Alcohol and Drug Addictions


Marijuana could help those who struggle with addiction by replacing the need for more harmful substances, according to recent studies.

 

The latest data, published in the journal Addiction Research & Theory, came from a survey of more than 400 medical cannabis patients across four dispensaries in B.C. When asked whether they ever used cannabis to replace pharmaceuticals, alcohol or illicit drugs, over 75% said they did.  

 

The largest portion, 68%, indicated using cannabis as a substitute for prescription drugs. 41% also said they used it for alcohol and 36% for other illicit substances, such as heroin or cocaine. 

 

Philippe Lucas, study co-author and research affiliate of the Centre for Addictions Research of BC, says the findings support cannabis as a potential treatment for drug addiction. He believes cannabis could act as an ‘exit drug’ when it comes to substance abuse – as opposed to a gateway.  

 

But more research needs to be done, since the study was only meant to identify a substitution effect and did not attempt to quantify it. Still, Lucas, who first came across the idea through his involvement with the Vancouver Island Compassion Society, believes there is now strong evidence that a substitution effect exists.

 

But the study was not the first to describe the phenomenon. In fact, it was conducted, in part, to replicate past work by another one of the study’s co-authors, Amanda Reiman of The School of Social Welfare at University of California, Berkeley.  

 

Reiman, who is also involved with the Drug Policy Alliance, published two studies on cannabis substitution between 2000-2009. 

 

Read More: Leaf Science

MMJ STUDY Marijuana Reduces Symptoms of Opiate Withdraw


Opiates are a powerful group of painkillers that include morphine, heroin and codeine. They are also highly addictive and pose a serious risk of overdose. Can marijuana help addicts quit? Researchers from Thomas Jefferson University seem to think so.

In a study published this month in The American Journal of Addictions, the researchers found that – out of 91 patients seeking methadone treatment – those who used cannabis experienced the least amount of withdrawal symptoms. 

Interestingly, prior to methadone treatment, those who used cannabis also seemed to spend less on their opiate habits than those who didn’t. On average, cannabis users spent $85 a day on opiates whereas non-users spent over $120. Overall, the researchers concluded: 

Although more research needs to be done, the authors cite a number of studies that support a role of marijuana in helping patients cope with opiate withdrawal. 

In a study published in 2005, patients reported cannabis to be more effective than cocaine, alcohol and nicotine, but less effective than benzodiazepines – drugs such as Valium – at easing withdrawal symptoms. Animal studies also provide “strong evidence for an ameliorative effect of cannabinoids on opiate withdrawal symptoms,” wrote the researchers.

While methadone is the most proven treatment for opiate addiction, it also happens to be a dangerous opiate as well. Methadone is responsible for about 5,000 overdoses per year in the U.S. On the other hand, the death count from cannabis is still at 0 and – as new findings seem to suggest – it may even be helping to prevent some. 

via: Truth on Pot

Get your FREE copy of The Marijuana Grow Bible from I Luv Growing Marijuana

Everything you need to know about growing marijuana

In my FREE e-Book you will learn the basics about growing marijuana. Both indoors and outdoors, from seed to harvest and everything else around growing marijuana. It’s not very difficult to grow huge buds, you just have to know how.

Even when you grow legally there are still some risks involved. Maybe thieves steal your marijuana plants because they’re worth a lot of money. Maybe your crop gets threatened by pests or diseases that can ruin your entire harvest. Or maybe there are other environmental factors that can be a bad influence on your marijuana plants.

Factors like temperature, air, water, nutrients and light are very important for the growth of marijuana. Placing marijuana seeds in the ground and letting them grow is certainly one way to produce plants, but you won’t get substantial yields.

It’s important to help your plants along the way, and this e-book will show you exactly how to do that.  You’ll learn the marijuana growing basics which include indoor and outdoor growth, the different stages of growth, and everything you can imagine about growing marijuana. It’s certainly not impossible to grow massive buds, you just need to understand how.

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