A peer-reviewed research study entitled "Neuroprotective Potential of Cannabis Sativa-based Oils in Caenorhabditis Elegans" published in the journal Scientific Reports explored "the protective potential of terpenoids [cannabinoids]" produced by cannabis and how they might play a potential therapeutic role in the treatment of diseases based in neurodegeneration, including Alzheimer's and Parkinson's.
The study observed that cannabis produces "hundreds of chemical compounds" by secondary metabolism and that these compounds include cannabinoids, terpenes, and other chemicals. "Among the cannabinoids, delta-9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) stand out as the two main ones," reported the scientists.
The study's authors "hypothesized that these oils [from CBD and THC] are effective in decreasing or delaying the symptoms caused by Alzheimer disease" and other diseases involving neuro-degeneration. It evaluated the protective potential of different concentrates of CBD and THC.
The scientists noted that such cannabinoids modulate the development, synaptic plasticity, and response to endogenous and environmental damage of the nervous system and that deficiencies or problems with any of these mechanisms leads to a number of neurodegenerative diseases that involve impairment to cognition, memory, and the senses, including behavioral disturbances.
"Through the interaction between cannabinoids and their receptors, an anti-inflammatory response is generated, which is an important strategy for maintaining physiological homeostasis and acting on the central nervous system, including pain reduction," reported the study.
The study reported that CBD "did not show as high an antioxidant action as THC under these test conditions." It noted that the endocannabinoid system receptors, "mainly CB1, are important biomarkers of body weight gain" and that many (but not all) cultivars (strains) of cannabis produce an increase in appetite.
The study concluded that cannabinoids such as CBD and THC may be effective in the treatment of neurodegenerative diseases due to a number of mechanisms, including anti-inflammatory, antioxidant, and other benefits.
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