CBD vs Breast Cancer


Cannabidiol (CBD) is gaining traction in medical circles and the public eye as increasing amounts of scientific literature confirm its medicinal qualities. These include CBD’s ability to stave off inflammation, curb anxiety, depression, PTSD, psychosis, and seizures.

More astonishingly, and perhaps more urgently, CBD is proving to be a powerful anticancer agent (as recently acknowledged by the U.S. government’s National Cancer Institute). A paper published by the American Association for Cancer Research found that CBD inflicts programmed cell death (PCD) in breast cancer cells.

In the introduction, the authors note:

“Breast cancer is the second leading cause of cancer-related death in women in the United States. Conventional treatment options are often limited by toxicity or acquired resistance, and novel agents are needed. We analyzed the effects of the Cannabis sativa constituent, cannabidiol (CBD), a potent, natural compound with reported activity in breast cancer cell lines, and elucidated its effects on key neoplastic pathways.

Later on in the paper, they write:

“We found that CBD inhibited the survival of both estrogen receptor-positive and estrogen receptor-negative breast cancer cell lines and induced apoptosis in a concentration-dependent manner. Moreover, at these concentrations, CBD had little effect on MCF-10A cells, nontumorigenic, mammary cells. These data enhance the desirability of CBD as an anticancer agent, because they suggest that CBD preferentially kills breast cancer cells, while minimizing damage to normal breast tissue.”

If CBD continues to shine in the laboratory as research continues, it holds the potential to augment or replace conventional treatments, such as chemotherapy, which often cause significant harm to healthy cells and may catalyze undesirable and potentially devastating side effects.

The authors of the paper explain that CBD coordinates apoptosis and autophagy, resulting in the death of breast cancer cells. Apoptosis (cell suicide) plays a vital role within our bodies. It is a form of cell death that facilitates the elimination of old and unhealthy cells without the release of harmful substances. 

Autophagy (cell recycling) is another normal physiological process by which the body breaks down unwanted cells. It maintains our homeostasis, or balance, by aiding the degradation of old cells and the formation of new ones.

More: Reset.me

Pain Patients Prefer MMJ not Pills


A newly released survey of nearly 3,000 medical cannabis patients found that nearly all respondents said they could reduce their opioid consumption after adding cannabis to their treatment regimen, and a vast majority preferred cannabis to prescription pills.

In a survey of its patients, the medical cannabis community website HelloMD asked a wide range of questions examining the use of cannabis as a substitute for opioid and non-opioid based pain medication. The study, conducted in cooperation with the University of California-Berkeley, was led by researchers Amanda Reiman and Mark A. Welty.

Among the key findings, 97% of respondents agreed or strongly agreed that they could decrease their use of opioid painkillers when consuming cannabis. And 92% said that they agreed or strongly agreed that they prefer cannabis to treat their medical condition.

Strikingly, 81% agreed or strongly agreed that cannabis alone was more effective than taking cannabis with opioids. This result was similar when patients were asked about consuming cannabis with non-opioid-based pain medication.

According to Reiman, cannabis could help with pain problems in patients who don’t want to take addictive opioid medications.

“The treatment of pain has become a politicized business in the United States. The result has been the rapidly rising rate of opioid-related overdoses and dependence,” she said. “Cannabis has been used throughout the world for thousands of years to treat pain and other physical and mental health conditions.”

Reiman added that she has been hearing anecdotal evidence from patients for years.

“Patients have been telling us for decades that this practice is producing better outcomes than the use of opioid-based medications,” she said. “It’s past time for the medical profession to get over their reefer madness and start working with the medical cannabis movement and industry to slow down the destruction being caused by the overprescribing and overuse of opioids.”

Dr. Perry Solomon, chief medical officer for HelloMD, agreed Reiman’s take.

“The latest publication from the National Academy of Sciences clearly refuted the ‘gateway drug’ theory that using marijuana can lead to opioid addiction, instead finding evidence of cannabis having multiple curative benefits,” he said. “Our study further substantiates this. Hopefully this will awaken the public, medical professionals and legislatures to the fact that cannabis is a safe, non-addictive product, available to help fight the opioid epidemic.”

via: Leafly

Marijuana Treats Migraine Pain Better Than Prescription Medication


In another win for marijuana research, a study has found that the active compounds in cannabis are more effective at reducing the frequency of acute migraine pain than prescription migraine meds, and with fewer side effects.

The study included a total of 127 participants who suffered from chronic migraines and cluster headaches, severe headaches that occur on one side of the head, often around an eye. Migraine pain usually affects both sides of the head and is often accompanied by light sensitivity and nausea.

The cannabis-based medication the researchers gave the participants was a combination of the two active compounds in marijuana: tetrahydrocannabinol (THC) and cannabidiol (CBD). THC is the psychoactive compound that gets pot users high; CBD doesn’t get you high, but research has shown that it provides therapeutic benefits, including relieving seizures in epileptic patients.

The study had two phases. In the first, sufferers of chronic, acute migraines were given varying doses of the THC-CBD drug. The results showed that those who received a 200mg dose each day for three months experienced significantly less pain--about 55% less (lower doses didn’t provide the same pain relief).

The second phase of the study included both those suffering from chronic migraines and those suffering from cluster headaches. Migraine sufferers were given either the THC-CBD drug or 25 milligrams of amitriptyline, an antidepressant medication often used to treat migraines. The cluster headache sufferers were given either the THC-CBD drug or 80 milligrams of verapamil, a calcium channel blocker med often prescribed for cluster headaches.

The results showed that THC-CBD was slightly better at reducing the frequency of migraine attacks than the commonly prescribed med (40.4 % versus 40.1%, respectively). And the THC-CBD drug was very effective at reducing migraine pain, cutting it by 43.5%.

The drug was also effective at reducing the severity of pain in cluster headache sufferers, but only if they had a history of migraines from childhood on.
The side-effect profile was also generally better than the common meds. People taking THC-CBD reported fewer stomach aches and muscle pains, and fewer incidences of colitis than those taking the prescription med. On the downside, those taking THC-CBD reported some drowsiness and difficulty concentrating.

The study reinforces earlier research showing that medical marijuana is effective at reducing the frequency of migraines, and it adds to a chorus of research findings pointing to marijuana compounds as less risky alternatives to prescription pain meds. A number of clinical trials are underway to determine whether drugs made from the compounds could supplant opioids as a go-to painkiller, and thereby lessen the burden of opioid addiction. Those trials will take some time, but it’s encouraging that research is moving steadily in the direction of discovering the therapeutic potential of marijuana compounds. With potentially enormous upsides, like reducing how many people are hooked on opioids, it's imperative that the research continues.

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