MMJ vs Opiate and Alcohol Withdrawal


Patients are using cannabis to help with withdrawal off of everything from opiates to alcohol, reporting that cannabis is lessening the process’ pain, cravings and complications. There is good scientific reason to believe these reports. Scientific studies support the theory that cannabis is able to lessen withdrawal related pain, agitation, insomnia, depression and boredom. Both human trials and personal experience back up lab and cell data.

Studies suggest cannabis diminishes addiction at the cellular level, lessening cravings and addictive behavior. In a 2009 French study, adolescent mice exposed to THC showed less addictive behaviors towards opiates than those who hadn’t been exposed. Several human studies show cannabis use increases the likelihood of successful withdrawal attempts from addictive substances like tobacco, heroin, alcohol and cocaine.

A 2013 review of the scientific literature found that “cannabinoids modulate brain reward systems closely involved in stimulants addiction, and provide further evidence that the cannabinoid system could be explored as a potential drug discovery target for treating addiction across different classes of stimulants.”

While cannabis stimulates our reward centers in similar ways to these addictive substances, it doesn’t come with the same physical risks. If patients were able to replace dangerous and often deadly substances like opiates, alcohol or tobacco with a safer substance like cannabis, for many this would be a lifesaving treatment. This argument is supported by the fact that in states like Colorado, where cannabis was legalized, deaths from opiate overdoses have gone down by 25 percent. When patients have access to a less harmful alternative to their painkillers, they are able to replace or lower their use with something safer.

More at: Cannabis Now

MMJ vs ADD and ADHD


It's already been a known fact that marijuana can work wonders most especially when it comes to the medical field. It is known to cure cancer and chronic illnesses, it is also said to reduce the symptoms of several mental illnesses. As per Chronic Pain Solutions, a recent study revealed that weed is actually better than Adderall in relieving ADHD.

Medical marijuana is said to be more effective than the usual ADD [Attention Deficit Disorder] or ADHD [Attention Deficit Hyper Activity Disorder] prescription drugs as it does not have the unpleasant side effects and the risk of infections. It is no longer a secret that numerous states have legalized medical marijuana and even the recreational use of the plant as it was found to provide endless health benefits.

One of the latest studies from Germany emerged wherein scientists focused on studying 30 patients diagnosed with ADHD who were not able to get the much-needed relief from Adderall and Ritalin. All 30 individuals are said to have improved their sleep and concentration after using marijuana. In addition to its effects, patients also experienced reduced impulsivity as a result of marijuana consumption.

22 out of 30 patients decided to pursue their medical marijuana treatments even after the study was over, as they would opt to use marijuana to manage their ADD symptoms. Dr. David Bearman, head of the cannabis research, mentioned that the effectivity of marijuana among ADHD treatment has to do with the dopamine level in the brain.

"Cannabis appears to treat ADD and ADHD by increasing the availability of dopamine," Bearman stated. "This then has the same effect but is a different mechanism of action than stimulants like Ritalin and Dexedrine amphetamine, which act by binding to the dopamine and interfering with the metabolic breakdown of dopamine."

MMJ vs Rheumatoid Arthritis


Rheumatoid Arthritis (RA) is a type of chronic arthritis that affects joints on each side of the body. It is characterized by joint pain, swelling, stiffness, and fatigue.

Cannabis has been used to help treat the inflammatory symptoms of rheumatoid arthritis for years. Despite the anecdotal success, past research offers little insight into the mechanism involved in treating the condition with cannabis.

A recent study to be published in Rheumatology does just that, suggesting that the benefits could be attributed to activation of the CB2 receptor.

Before diving into the study, it’s helpful to know that fibroblast-like synoviocytes (FLS) are the type of cells most often associated with Rheumatoid Arthritis. They become constantly engaged in inflammatory mechanisms, which causes cartilage damage, joint destruction, and deformation over time.

As we know, there are currently two widely-acknowledged cannabinoid receptors. Some suggest that more could exist, but not all are in agreement. Nonetheless, activation of the CB2 receptor, in particular, has shown promise in treating a number of inflammatory conditions.

A team of researchers from China sought to determine whether a similar mechanism could be beneficial for rheumatoid arthritis. In doing so, they investigated the potential effects of CB2 receptor activation in FLS-cell types.

According to their results, rheumatoid arthritis cell-types showed an increased amount of CB2 receptor expression. Further, activating the CB2 receptors seems to have inhibited the proliferation of the FLS cells associated with rheumatoid arthritis.

In conclusion, the Chinese team of researchers determined that activation of the CB2 receptor – which occurs when one consumes cannabis – could be a potential therapeutic target of for those suffering from rheumatoid arthritis.

Of course, the idea of applying cannabis extracts to the skin is nothing new. Cannabis infused topicals are a common method of treatment for joint pain because they allow patients to target the areas in need of the most relief.

via: Medical Jane

Alcohol Cannabis and Aggression


Scientists researching the effects of alcohol and cannabis on aggression proved what many people already know – alcohol makes people more aggressive, and cannabis makes people less aggressive. The researchers recruited a balanced group of drinkers, smokers, and sober participants for their trial, and utilized a series of tests to gauge their aggression.

After the intoxicated participants were pass through the study, they were asked to take the tests again a week later sober to act as a sort of additional control group. On a side note, those familiar with the research on this topic would know that alcohol is both more addictive and harmful than marijuana.

This team followed the most respected protocol available, choosing a random controlled trial as the study’s format. The trial was comprised of separate tests. The first test was a “single category implicit association test”, in which participants are asked to match positive and negative words with photos showing aggressive actions.

The second test was a computer game in which the participants were told they were able to win money by pressing buttons in a game against another study participant. In this head-to-head competition, the participants were actually playing against a computer-controlled opponent. The researchers gauged the aggression level of the participants, by asking each to self-score their level of aggression on a 100-point scale before and after each test.

Those who were in the alcohol group were observed to have increased subjective levels of aggression when intoxicated. In other words, the drinkers in the study self-reported that they felt more aggressive when drunk as compared to when they are sober. Conversely, the smokers in the study self-reported that they felt less aggressive when high.

When playing the computer game during the study, the drinkers tried harder to undermine their opponents when drunk, whereas the smokers acted less aggressive in the game while high. Shocking! Anyone with personal experience of both alcohol and cannabis already knows this from first-hand experience.


The researchers summed up the findings of their research by concluding that “the results in the present study support the hypothesis that acute alcohol intoxication increases feelings of aggression and that acute cannabis intoxication reduces feelings of aggression.” Stories of crazy people doing crazy things while high are “tragic outliers”, and do not reflect the reality of the effects.

More at: Whaxy

CBD vs OCD


Presently, obsessive-compulsive patients are often treated with selective serotonin re-uptake inhibitors (SSRIs), like the antidepressant Prozac, in addition to psychotherapy. With that said, a team of researchers published a study in the journal Fundamental & Clinical Pharmacology earlier this month that investigated cannabidiol (CBD) and its ability to help treat rats with OCD.

The research team, which represented the Department of Pharmacology at the University of Sao Paolo, was led by Dr. Francisco Guimarães. First, they administered Meta-chloro-phenyl-piperazine (mCPP) – a psychoactive drug that is often found in ecstasy pills. It is known to induce panic attacks in those prone to having them and has been determined make symptoms of OCD worse. Further, the study adds that mCPP is been known to inhibit the anti-compulsive effects of SSRIs.

Once mCPP was administered, the researchers conducted a “marble-burying test” with the rats in order to evaluate OCD activity. Low doses of the drug, according to the study, was found to increase marble-burying tendencies in rats, while large dosages seemed to decrease them. There was, however, no difference in noticeable anxiety behaviors.

The researchers then administered two levels (30mg/kg or 15mg/kg) of cannabidiol (CBD) and evaluated the obsessive-compulsive activity in each rat. Interestingly, even a low dose of CBD decreased the marble-burying behavior without a change in the rats’ overall activity level.

According to the study, its results reinforce the possible anti-compulsive effect of cannabidiol (CBD). More research will be necessary before CBD is used to treat obsessive-compulsive disorder in a clinical setting, but findings such as these suggest that cannabis may be a valuable tool in OCD treatment.

More about CBD and OCD: Medical Jane

MMJ Fatigue and Depression


In the ongoing debate about the draws and drawbacks of medical marijuana, the discussion of depression is among the most contentious.

Some say marijuana has incredible, positive effects on those suffering from depression, as well as related symptoms such as fatigue, chronic pain, stress, and anxiety.

Others say it does nothing, or even worse, brings people’s moods down. This is an extremely worthwhile subject to investigate and hopefully reach conclusions about, as millions suffer from depression, and medical marijuana is certainly on the cusp of great pervasiveness in society.

Let’s turn first to a study from the University at Buffalo. The findings weren’t all concrete, but the 2015 work suggests that depression linked to chronic stress–a major and frequent factor in both temporary and long-term, clinically diagnosed episodes–can seemingly be positively altered by the use of marijuana.

It all comes down to the role stress plays in ebbing away at naturally produced chemical compounds in the brain called endocannabinoids. And if that canni root word reminds you of a certain sprawling green leaf, it’s because the chemical is closely related to ingredients found in pot, such as the oft-mentioned THC.

By smoking marijuana, it is suggested that people can restore this eroded chemical and help balance their mood. While the study’s writers and others have since continued exploring the idea for utmost verification–it was originally done on animals–there’s good reason to believe it has some veracity to it. After all, marijuana has been used both medicinally and via self-administration for a long time, particularly as a relief agent for stress and post-stress disorders.

If you’re looking for a study that sounds a little more like the doctor’s orders, you should read up on McGill’s 2007 work. All in one source, the Montreal university cleanly and clearly states the benefits and dangers of using medicinal marijuana for depression.

Their bottom line? Pot helps with depression—as long as you don’t smoke too much. Indeed, research both in the lab and on the sofa can agree: It feels good to smoke marijuana; just don’t go overboard!

More: The Medical Marijuana Association 

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