CBN Cannabinol Explained


When we look at the construction of cannabis, we find that it has over 80 cannabinoids. Until recently, tetrahydrocannbinol (THC) was the only cannabinoid anyone seemed to care about. Thankfully recent research, particularly about cannabidiol (CBD), has brought about an intense interest in all the cannabinoids.

As is the case in many of the known cannabinoids, cannabinol (CBN) stems from cannabigerolic acid (CBGA) in cannabis. The plant naturally produces enzymes (aka synthases) that convert the CBGA to one of 3 major cannabinoids: cannabichromene carboxylic acid (CBCA), cannabidiol carboxylic acid (CBDA), and tetrahydrocannabinol carboxylic acid (THCA).

When the plant develops THCA, it usually will be converted to THC as a result of heat or UV light. That being said, THCA can be converted to CBNA over time as well. Prolonged exposure to air causes the THCA to lose hydrogen molecules and oxidize; now we have CBNA. Just like the rest of the acidic cannabinoids, CBNA will convert to cannabinol (CBN) when exposed to heat or UV light.

Cannabis is widely used as a sleep-aid for those who suffer from insomnia and cannabinol is the reason why. By all accounts, CBN is the cannabinoid responsible for the sedative effects of cannabis. Because of this, I tend to reserve high-CBN strains for night use.

Another use for cannabinol as an anti-bacterial. According to a Italian study from 2008, cannabinol “showed potent activity against MRSA” when applied as a topical. Topical uses also have shown promise in treating burns and psoriasis.

The research on cannabinol (CBN) is still lacking, but some early studies have suggested it could stimulate bone growth. If that’s the case, it would be helpful in treating osteoporosis. It could also help those with broken bones to recover more quickly.

When searching for the perfect strain, it’s important to know what you’re getting. This is why lab-testing should never be overlooked. Testing facilities like Steep Hill Lab in California give patients a complete cannabinoid profile of their medicine. It’s always a good idea to check a strains profile before making a decision.

Because cannabinol is a production of degradation, it’s not usually found in high concentrations (in a collective). High levels of CBN are usually related to poor storage methods. If cannabis is stored in an airtight container of some sort, it’s unlikely that a lot of THC would convert to CBN.

Luckily, not all is lost if you’re searching your collective for a sleep-aid. The simple solution would be to allow you’re medicine to age a bit. When exposed to the air, the THC will begin to degrade and convert to CBN, a great way to fight insomnia.

via: Medical Jane

Two Must Haves for every Dab Lover

The Nail Crown and Hustle Butter from Cruz Culture



The Nail Crown

The Nail Crown peaks curiosity on the first glance. Once you start taking it apart and checking it out, you quickly realize that the Nail Crown reveals quite a few indispensable uses.

The Nail Crown is made of Platinum Grade Silicone and is able to withstand temperatures up to 700º F. Cover, remove and store hot nails without burning your fingers. Store your concentrates right up top and secure with the tight fitting lid and have your dabs right there when your ready to heat things up.

Have all your tools at the ready and a place to store them when your done. With everything in one place, never leave your valuable concentrates, tools or your nail behind again.

The Nail Crown is available in a variety of colors including some color changers and glow-in-the-dark options. There is even a handy spot hidden in the base for Nail Crown Antimicrobial Wipes to keep your glass sanitary and safe.




Hustle Butter

Having a little Hustle Butter handy is a good idea for any dabb lover. Hustle Butter is a Vegan Certified Natural Residue and Odor Remover. No more sticky smelly fingers or dried out lips.

Both the Nail Crown and Hustle Butter easily fall into the list of dabbing must haves. No more burned, sticky or stinky fingers and no more searching for your nail, concentrates and tools when you a ready to enjoy.


Check out the Nail Crown and Hustle Butter 
at Cruz Culture
and get 10% OFF any purchase with Code: MRSTINKYS

Medical Marijuana vs Melanoma


An in-vitro and in-vivo study published in the Journal of Investigative Dermatology in February 2015 found that treatment with delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) helped to decrease the viability of melanoma cells.

Cells perform autophagy, a process designed to clean out intracellular debris (e.g. old cell parts [organelles], proteins that are no longer needed, etc.) with the help of lysosomes (organelles that contain enzymes that help to break down proteins, fats, sugars, DNA and RNA building blocks, etc.). Previously collected evidence has shown that in the first phases of cancer development, autophagy is useful in helping to prevent cancerous growth. 

However, in later stages, autophagy may actually contribute to the formation of cancer by providing resources to cancer cells that help in maintaining survival. In this study, researchers explored whether or not cannabinoids could induce apoptosis (i.e. programmed cell death), and what role autophagy played in this induction, in melanoma cells.

Studying human melanoma cells in-vitro (i.e. outside of the body), researchers found that administration of THC helped to increase melanoma cell death by way of autophagy-dependent apoptosis, possibly by way of the following pathway:
  • THC leads to creation of a fat called sphingolipid ceramide.
  • Sphingolipid ceramide leads to (1) stress on the endoplasmic reticulum (ER; the smooth ER is a part of the cell involved in lipid and carbohydrate metabolism, as well as detoxification, and the rough ER is a part of the cell involved in protein synthesis) and (2) prevention of the Akt/mTORC1 signaling pathways (which prevent apoptosis by inhibiting autophagy, and lead to increased protein production, helping to keep cells alive and functioning properly) through activation of the protein TRIB3.
  • This stress and prevention of pathways leading to increased cell survival may lead to increased death of melanoma cells.
The researchers note, “when lower doses of THC are combined with CBD the anti-tumour effect was enhanced in vitro”. While the use of THC alone helped to decrease melanoma cell survival, use of a caspase inhibitor (i.e. an agent that prevents activation of enzymes that induce apoptosis) helped to increase melanoma cell death even further. Importantly, while THC helped to increase cell death in melanoma cells in a dose-dependent manner (i.e. the higher the concentration used, the more cell death that occurred), there was no increase in cell death in normal melanocytes (up to a THC concentration of 6 µM, which is beyond the concentration needed to induce cancer cell death). Therefore, THC treatment destroyed abnormal/cancerous melanocytes, but, importantly, did not destroy normal cells.

These results add to a growing body of evidence that suggests that cannabinoids may be useful for the treatment of various types of cancer (breast, prostate, lung, skin, pancreatic, brain, bladder cancer, leukemia). Specifically, they demonstrate that the use of phytocannabinoids may be useful in the treatment of both BRAF-mutated and BRAF-wildtype (i.e. “normal” BRAF) melanoma. This is especially important for patients with BRAF-wildtype melanoma, given the limited treatment options for this form.

In contrast to alkylating agents used in chemotherapy treatment, phytocannabinoids have so far shown to have a highly favorable safety profile, which provides an additional rationale for increasing research on whether or not cannabinoid therapies are effective for the treatment of cancer, including melanoma.

More at: Medical Jane

REVIEW The Vape710


The Vape710 is truly unique. The combination of a portable charging station and the two cigarette sized vaporizers make the Vape710 not only one-of-a-kind but also quite practical and convenient to use.

The charging station case insures all day vaping and also provides protection for the vaporizers. You no longer have to worry about breaking your vape pen in your pocket or when it falls over on your desk. The charging station case carries enough power to get you thru any day. While testing the Vape710, I went two days of regular and continuous use without charging and only plugged it in because I didn’t know if it would make it thru a third day. Considering the fact that I haven’t charged it since, leads me to believe it probably would have been just fine for the extra day.

The main benefit is the two separate vaporizers. You can have one vaporizer loaded with the fun stuff and the second loaded up with any e-juice or some CBD oil to help you kick that cigarette habit or have a separate medicinal therapy at the ready.

The size of the individual vaporizer is a hair thicker than a regular cigarette and slightly longer than a King and shorter than a 100. There are no buttons or switches because the vaporizer is activated by inhaling with the same draw as a cigarette. The wicks are at the very bottom of the cartridge and situated to get the last drop and waste nothing.

The last benefit I want to mention is that using a vaporizer the size of a cigarette is very convenient when you are trying to be discreet. The instant on when you draw operation means that you need only duck out of view for a moment to enjoy.

Overall I give the Vape710 high marks for being unique, discreet, convenient to use and always ready to go.



Check out the Vape710 at vape710.ca
and Get 10% OFF with Code: MRSTINKYS
when you order.



BCP the Cancer Fighting Terpene


Beta-caryophyllene, also known as BCP, is a terpene that contributes to the spiciness of black pepper and is also present in oregano, cloves, hops, rosemary, and cannabis. It was first synthesized in 1964, but it wasn’t until 2008 that European scientists discovered that it has cannabinoid-like properties. Like many other cannabinoids and terpenes, BCP targets the body’s CB2 receptors, ignoring the CB1 receptors that are involved in delivering the euphoric high associated with cannabis and, more specifically, the THC cannabinoid.

BCP is often categorized as a cannabinoid, not a terpene, because of how it binds to CB2 cannabinoid receptors. It is not only found in several legal herbs and spices, but is even an FDA-approved food additive. For this reason, some sources label BCP the “first dietary cannabinoid.”

Because it targets CB2 receptors and delivers no high, BCP is an effective way to medicate while avoiding any alteration in perception or motor skills. It can be used to treat several inflammatory disorders, including arthritis and multiple sclerosis. Like its cousins pinene and limonene, BCP has also been shown to fight cancer, reduce anxiety and depression, and has even been found to be gastroprotective — meaning it can be used to treat ulcers.

BCP also is helpful for those suffering from atherosclerosis and osteoporosis and can even increases bone mass and blocks pain signals, all while avoiding any interference with the nervous system. Because so many other cannabinoids and terpenes act as analgesics (pain killers), BCP is more evidence of the entourage effect, a theory explaining how a variety of terpenes and cannabinoids work synergistically to improve health or fight disease.

A study published in 2014 in the journal Pharmacology Biochemistry and Behavior revealed that a variety of cannabinoids bind to CB2 receptors and may help in the treatment of alcoholism. In the study, researchers injected BCP into animal models and found that activating CB2 receptors resulted in decreased ethanol (alcohol) consumption and preference.

Because BCP is not exclusive to cannabis and has been approved by the FDA as a food additive, it is fully legal. There is tremendous opportunity for food manufacturers, pharmaceutical companies, and herbal remedies to utilize BCP as a tool in the fight against a long list of ailments, including cancer, depression, ulcers, pain, and even osteoporosis.

Much More at: Whaxy

The Toker Poker at the Champs Trade Show Las Vegas Feb 2016


The Toker Poker was created like every great product – as a matter of necessity. 

After constantly finding ourselves in search of a poker, we simply asked ourselves: why isn’t there a product with a poker and tamper attached to the lighter? Days later, at our kitchen table, the first prototype was born. 

Quickly, it drew attention from our friends and what started as a pipe dream suddenly became a reality. 

So here we are 3 years later, after countless designs, redesigns and prototypes with a truly unique and utterly necessary product. Finally your poker, tamper and lighter are all in the same place. It’s the perfect companion for all your adventures – rejoice all powder seeking, wave shredding, festival flowing, trail blazers out there – because, not all of us get stuck on the couch.

More at: TokerPoker.com

  

Boveda at the Champs Trade Show Las Vegas Feb 2016


Only Boveda’s patented technology adds or removes humidity as conditions require to maintain the right moisture content of cannabis. That means a better experience and no weight lost to evaporation. The right moisture content of cannabis maximizes the color, taste, aroma and efficacy while stabilizing the weight.

Boveda is ideal for storing and curing (aging) cannabis that has already been dried. While Boveda is effective in moisture removal, the standard method of hanging in a dry environment is most effective. When you feel the plant is close to the intended moisture content for curing, Boveda will do the fine tuning for perfect long term storage. Grow it, dry it, package it with Boveda. You get perfect long term curing for the best possible cannabis.

More at: Boveda


The Kasher at the Champs Trade Show Las Vegas Feb 2016


OG Kash was the original Kasher created, specifically made to fit snugly around classic Bic lighters. Due to popular demand, OG was followed by our Kasher Plus line which introduced color options.

Later, both the OG and K+ were improved with thicker metal for extra durability, while K+ was also improved with permanent coloring and smoother sliding action.

The Kasher product line now includes 2 new types: Kasher Mini for those who carry Bic Mini lighters, and Kasher Klipper specifically to equip Clipper™ lighters. Soon after these we completed 2 more developments – what a busy year! We released Kasher Vape to fit over vape pen batteries; and the special, hand-modified Kasher Titanium for concentrate users.

More at: MyKasher.com 




Incredibowl at the Champs Trade Show Las Vegas Feb 2016


The Incredibowl i420 is the product of countless hours of research, design, development and testing. 

Combining a compulsive fascination with physics and obsessive attention to detail, Incredibowl created a pipe that actually makes it easier and more enjoyable to smoke. 

In only six years, the original Incredibowl i420, the pocket-sized Incredibowl m420, and the family of add-ons and accessories they’ve spawned have become some of the best-selling pieces in the world, and have been selected by fans to win a record-shattering 19 High Times Cannabis Cups.

More at: Incredibowl.com


HEMPDOX CBD at the Champs Trade Show Las Vegas Feb 2016


HempDox keeps Mother Nature in the equation and is dedicated to bringing you natural CBD products with
actual effectiveness.

100% natural high concentrate CBD Vapor Oil and other natural pure ingredients ensure high quality and safety. 

Nano-formulation within high energy homogenization system delivers an incredible smooth blend with purity, stability and consistency, nature changes, thus HempDox adjusts formulation for each batch in order to have stable outcomes. 

CBD Potency Tested
Pesticide Tested
Residual Solvent Tested
Heavy Metal Tested
Terpenes Tested
Microbiological Tested
100% Natural Tested 
 
More at: HempDox.com
 
 

Lifted Innovations at the Champs Trade Show Las Vegas Feb 2016


We, here at Lifted Innovations, fully indulge ourselves in a 3D life we have created around us. 

We take everyday as an opportunity to achieve great things, so we never take time for granted. Everyone wants to see the future before they’re no longer here to see it… we’re here to print it and put it right into your hands. Don’t blink

More at: LiftedInnovations.com

  

Eyce Mold at the Champs Trade Show Las Vegas Feb 2016


The Eyce Mold 2.0 gives you a new level of freedom and benefits that has never been reached with any smoking device before it. Creating your own water pipe at home is the ultimate advancement in clean, crisp, endless cold smoke. 

Eyce Mold's offer all the benefits of glass, without the worry of breaking. One investment gives you water pipes for life. Our product even includes a lifetime warranty! Never worry about the drunk person at the party or your dogs wagging tail breaking your water pipe again. In fact, you can just shatter your water pipe for fun!

Eyce has eliminated the dirty gross water pipe, no more stinky water pipes around your house. Eyce Water Pipes are always fresh and always clean. Making a new Eyce Pipe is far easier than cleaning a dirty glass piece. The process always involves fresh clean water rather than a nasty alcohol, salt, resin mess. Also, by purchasing additional accessories you give yourself the ability to always have a fresh back-up pipe ready to go with no wait for freezing.

Easy to travel with! Evidence just melts away...

Scientifically proven to be the coldest smoke on the market! On average, the Eyce 2.0 delivers a smoke that is about 10-15 degrees Celsius colder than a glass water pipe with ice cubes.

On top of all that it's fun! 

More at: EyceMolds.com




Shine 24 Karat Rolling Papers at the Champs Trade Show Las Vegas Feb 2016


Shine Papers is the inventor of the worlds first ever 24 karat gold rolling paper. 

The brand quickly gained popularity and became the "go to" brand for those who celebrate all of life's highs.
 
Not only do Shine Papers turn every head in the room, but the papers also burn extremely slow while also leaving behind a "gift" in the ashtray. Yup, the gold stays on your ashes which are referred to as "the gems" but unfortunately you cannot pawn your ashes.

More at: ShinePapers.com 


The Easy Butter Maker at the Champs Trade Show Las Vegas Feb 2016


The Easy Butter Co. herbal butter infuser is your key to the fastest way to infuse herbal butter and oil with  "No Straining!" 

Easy Butter Co, is 100% committed to quality products with fast delivery. So, grab your Easy Butter Maker today so you can get started putting the "Fun Back in Your Baking!"

More at: EasyButter.com 


Firefly 2 at the Champs Trade Show Las Vegas Feb 2016


The Firefly is the only loose-leaf vaporizer that heats up instantly. Its sophisticated electronics ensure reliable digital temperature control to heat your favorite tobacco to vaporization without burning it. Because there are no plastics in the air path, the Firefly delivers smooth, consistent vapor with no unwanted tastes or smells. Enjoy pure vapor and nothing else.

Dynamic convection heating delivers the full range of desirable flavors and active ingredients for an experience that tastes, smells, and feels superb.

More at: FireFly.com




The Smoke Buddy at the Champs Trade Show Las Vegas Feb 2016


The Smokebuddy is a handy, and reliable, life saving air filter. Simply exhale your smoke through your easy-to-use Smokebuddy and odorless air comes out the other end. Smoke where you want, and when you want without anyone knowing the wiser. Keep second hand smoke away from friends, family, and neighbors with your Smokebuddy.

More at: SmokeBuddy.com 


EZJ Buzz at the Champs Trade Show Las Vegas Feb 2016


The EZJ system allows for factory like precision at home. You can roll your favorite paper into an EZJ and then simply fill and go.  

We designed our Non-Filter to allow a full spectrum of medicine in...  EZJ doesn't filter, in fact it out flows anything on the Market. 

Benefits include:
EZJ rarely runs saving your medicine & money, •
Firm Crutch = No Waste = No Roach
Unlimited Crutch & Paper Options. Reg-King Size
No Pipe = No Paraphernalia Charges... Non-medical states can't stack charges this way.
The fastest easiest way to roll and fill in 30 seconds
Steath by Design,  Crutch covers make your EZJ look like a cigarette. 


More at: EZJ Buzz
Twitter: @wwwEZJBuzz 


Randys PILOT and TREK at the Champs Trade Show Las Vegas Feb 2016


Randy’s (NEW) TREK Dry Herb Vaporizer is packed with innovative technology for your dry herb vaping needs. In 3 seconds it heats to 428F. The deep ceramic dish can fit your favorite dry herb for vaping on the go. There is no exposed coil so your dry herb will evenly bake. The kit is loaded with all the essentials needed to have the best experience with your TREK. 

The TREK and Everything at Randy's 
10% OFF with Code MRSTINKYS


 Randy’s (New) PILOT Concentrates Vaporizer is your pocket-size vaping companion for concentrates. In 4 seconds it heats to 480°F, but can reach temperatures as high as 842°F. The no splash ceramic chamber makes it easier to place your concentrates on the heating element. Use your included dab tool/cover to be in full control of your vaping experience. 

The PILOT and Everything at Randy's 
10% OFF with Code MRSTINKYS

The DaVinci Ascent Vaporizer at the Champs Trade Show Las Vegas Feb 2016


Sleek, stylish and discreet. The Ascent features a 100% all-glass pathway, glass-coated ceramic bowl, a 3-hour battery life and a staple precision temperature control. All of these features offer absolute flavor and incomparable purity every time you vape, this makes the Ascent the perfect choice of new users and advanced vaping connoisseurs.

The Ascent comes in a variety of designs including Stealth, Carbon Fiber, Burl Wood, Croc Skin and Black Skulls. You can also personalize your vaporizer with custom designs.

More at: DaVinciVaporizer.com 
Twitter: @DaVinciVape

Get 10% OFF Everything at Da Vinci
with Code: MRSTINKY10

  

The Cruz Culture Nail Crown at the Champs Trade Show Las Vegas Feb 2016



The Nail Crown is the authority in dabbing technology and safety, created in order to solve the most common issues while enjoying concentrates. 

Never burn yourself again and easily take your dabbing tools on the go with a platinum grade silicone Nail Crown which allows you to grab and store heated nails. Beyond that, use your Nail Crown to hold dabbers, store concentrates and even hold your phone so you can record that epic dab! The Nail Crown dabbing tool is HotBox Approved for its superior quality and safety.

Safe: Cover or remove your hot nail without the risk of getting burned.

Mobile: Never wait for your nail to cool down. Great for events and travel.

Store Dabs: The medical grade platinum cured silicone container can also store your concentrates.

Toolbox: Keep all the dab tools you need inside of the Nail Crown so you don't misplace or break them.

More at: CruzCulture.com 

The Nail Crown and Everything 
at Cruz Culture 10% OFF 
with Code MRSTINKYS



Pyptek at the Champs Trade Show Las Vegas Feb 2016


The Prometheus line by Pyptek is designed to be virtually indestructible. Pyptek has dropped pyps down mountains and run them over with trucks and haven’t managed to break one yet. 

Unlike regular glass pipes, Pyptek has engineered their pyps to withstand the elements, so you can take it on any adventure you can imagine. 

The pyps were designed utilizing an exoskeleton model: a borosilicate glass core is sheathed in industrial grade rubber, which is then encased in an anodized, aircraft-grade aluminum shell. 

Thanks to all of the crustaceans and bugs out there for the inspiration. 

You can see for yourself the indestructible power of the Pyp HERE, and check out the engineering behind each of our Pyps: NANO, POCKET, TITAN & EMBYR


More at: Pyptek.com

  


Higher State Creations at the Champs Trade Show Las Vegas Feb 2016


Add a little color to your glass with a purpose. 
Check out Higher State Creations.

&





Transformer Tubes at the Champs Trade Show Las Vegas Feb 2016


Transformer Tubes are a family of interchangeable modules that can be assembled to create many different combinations of smoking pipes and hookahs. By utilizing a standard interface, every module can associate with every other module via male and female threads.

By splitting the smoking device into multiple components, Transformer Tubes are able to solve several shortcomings of the one and two piece pipes/hookahs.

• Each module can be disassembled from the other modules, and are sufficiently sized to be filled under a faucet or safely drained.

• Transformer Tubes implement a modular design, so replacing a broken module is far cheaper than purchasing an entirely new pipe.

 • You are able to quickly and efficiently “break down” your hookah or pipe into disassembled modules for transportation ease and security.

• Modularization allows for easy cleaning of all parts

• Transformer Tubes are 1/5th the weight of their glass counterparts.

• Because the modules are made out of plastic, they are far more durable than glass.

More at: TransformerTubes.com
Twitter: @TransformerTube

10% OFF All Transformer Tubes with
Code: MRSTINKYS


 

Elevate Accessories 10% OFF w/Code MRSTINKYS

Elevate Accessories 10% OFF w/Code MRSTINKYS
Heirloom Quality Smoking Accessories that are made to Last a Lifetime

Everything at Randy's 10% OFF with MRSTINKYS

Everything at Randy's 10% OFF with MRSTINKYS
Wired Rolling Papers, Hemp Wicks, Cleaners, Vaporizers and More

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