Past research has implicated CBD in the treatment of Alzheimer’s disease because of its antioxidant, anti-inflammatory and neuroprotective effects, but due to the irreversible nature of the disease’s progression, real breakthroughs are hard to make. For the first time ever, scientists in Australia looked at what long-term oral CBD administration does, and found that it improves social recognition in mice with Alzheimer’s.

One of the most dramatic and disturbing symptoms of Alzheimer’s disease is the loss of social recognition; many patients fail to recognize even their own children. Seemingly irreversible changes happen in the brain when a person gets Alzheimer’s, making treatment of the disease very difficult.

CBD had previously been shown to offer some help as a neural antioxidant in preclinical trials on mice, but without real improvement in their mental state. By using special transgenic mice breed to succumb to the disease, scientists were able to analyze the effects of what preventative CBD treatment does, and the results were impressive. Mice that took 20 mg/kg of CBD (equivalent to almost a gram and a half for someone of average weight) every day before showing symptoms of Alzheimer’s didn’t develop social recognition deficits, even in the middle of full-fledged Alzheimer’s disease. While some other symptoms were still present, the mice generally had better cognition if they took CBD for long periods of time. The scientists think that “this prevention may be linked to CBD-induced retention of dietary phytosterols or neuroinflammatory processes in the brain” of mice with the disease.

With daily progress in genomic research, so-called “personalized medicine” will allow doctors to preventatively treat diseases before they even happen. Mutations on certain chromosomes can whether or not a person is at risk for developing Alzheimer’s; CBD may one day be used to help these people lead a better life.

Photo credit: DankNaturally

via: High Times