Researchers at the Meir Medical Center, Department of
Gastroenterology and Hepatology in Israel assessed the safety and
efficacy of inhaled cannabis versus placebo in 21 subjects with Crohn’s
disease who were nonresponsive to conventional treatments.
Eleven participants smoked standardized cannabis cigarettes containing 23 percent THC and 0.5 percent CBD (cannabidiol) twice daily over a period of eight weeks. The other ten subjects smoked placebo cigarettes containing no active cannabinoids.
Investigators reported, “Our data show that 8-weeks treatment with
THC-rich cannabis, but not placebo, was associated with a significant
decrease of 100 points in CDAI (Crohn’s Disease and activity index)
scores.” (The CDIA is a research tool used to quantify the symptoms of
Crohn’s disease patients.) Five of the eleven patients in the study
group also reported achieving disease remission (defined as a reduction
in patient CDAI score by more than 150 points).
Researchers also reported that “no significant side effects” were
associated with cannabis inhalation. Subjects in the study group
reported improvements in appetite and sleep compared to those in the
placebo group. Cannabis inhalation was also associated with
“significantly less pain” among the participants.
The study is the first placebo-controlled clinical trial to assess the consumption of cannabis for the treatment of Crohn’s.
Courtesy: Hawaii News Daily
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